Decellularised extracellular matrices promote mesenchymal stem cell expansion and support osteogenic differentiation
نویسندگان
چکیده
منابع مشابه
Calcium phosphate surfaces promote osteogenic differentiation of mesenchymal stem cells
Although studies in vivo revealed promising results in bone regeneration after implantation of scaffolds together with osteogenic progenitor cells, basic questions remain how material surfaces control the biology of mesenchymal stem cells (MSC). We used human MSC derived from bone marrow and studied the osteogenic differentiation on calcium phosphate surfaces. In osteogenic differentiation medi...
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Bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. Recently, various stem cells, including embryonic stem cells (ESCs), bone marrow-derived mesenchymal stem cells (BM-MSCs), umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs), adipose tissue-derived stem cells (ADSCs), muscle-derived stem cell...
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Currently, autologous bone grafting represents the clinical gold standard in orthopaedic surgery. In certain cases, however, alternative techniques are required. The clinical utility of stem and stromal cells has been demonstrated for the repair and regeneration of craniomaxillofacial and long bone defects although clinical adoption of bone tissue engineering protocols has been very limited. In...
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Introduction In vitro expansion and differentiation of mesenchymal stem cells (MSCs) rely on specific environmental conditions. One crucial factor is the oxygen tension. Low oxygen tension improves MSC expansion in vitro. Moreover, it accelerates the induction of a chondrogenic phenotype in subsequent 3D differentiation cultures. However, clones of MSCs from the same donor often differ in their...
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ژورنال
عنوان ژورنال: Frontiers in Bioengineering and Biotechnology
سال: 2016
ISSN: 2296-4185
DOI: 10.3389/conf.fbioe.2016.01.01611